Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

bactrim and alcohol

You are encouraged to report negative side effects of prescription drugs to the FDA. Advise female patients of reproductive potential that BACTRIM can cause fetal harm and to inform their healthcare provider of a known or suspected pregnancy . Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid . Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. Thus, sulfamethoxazole and trimethoprim blocks two consecutive steps in the biosynthesis of nucleic acids and proteins essential to many bacteria.

A secondary search was performed via review of references found from the initial search. All randomized controlled trials and results from smaller, nonrandomized, open-label studies were included, provided that the studies had adequate methodology as judged by the authors. For drugs with limited information, case reports/series were included. Online drug information centers for Walgreen’s, Rite Aid, and CVS pharmacies were queried for each antimicrobial for concurrent alcohol use warnings .

These studies are further limited by recall, selection, and information biases, and by limited generalizability of their findings. Lastly, outcome measures varied between studies, limiting cross-study comparisons. Alternatively, other epidemiologic studies did not detect statistically significant associations between BACTRIM exposure and specific malformations. Brumfitt and Pursell,10 in a retrospective study, reported the outcome of 186 pregnancies during which the mother received either placebo or oral trimethoprim and sulfamethoxazole. The incidence of congenital abnormalities was 4.5% in those who received placebo and 3.3% in those receiving trimethoprim and sulfamethoxazole. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester.

Drinking Bactrim and alcohol can increase the risk of nausea and vomiting occurring. It may be tempting to drink while taking antibiotics, but this is not recommended and can be dangerous. In terms of when it would be safe to drink alcohol after taking Bactrim, the drug is rapidly absorbed after taking a dose by mouth, with most of the medication being absorbed within a few hours. If you want to avoid consuming alcohol while Bactrim is absorbed from your stomach/GI tract, three to four hours seems to be that upper limit. This may help prevent any nausea or vomiting the combination might bring about.

What Are The Side-Effects of Bactrim And Alcohol

Drinking alcohol while taking prescription drugs can intensify these effects. You may have trouble concentrating or performing mechanical skills. Small amounts of alcohol can make it dangerous to drive, and when you combine alcohol with certain prescription drugs, you put yourself at even greater risk. You should not drink alcohol while taking Trimethoprim and Sulfamethoxazole tablets, such as Bactrim. It can cause several adverse effects and can also cause dangerous heart rate elevation and decreased blood pressure.

bactrim and alcohol

Depending on the dose and your individual metabolism, side effects may range from mild to severe and may include nausea, vomiting, dizziness, headaches, and an altered mental state. If you choose to drink alcohol while taking Bactrim, it is important to drink responsibly. Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat various bacterial infections. It consists of one part trimethoprim to five parts sulfamethoxazole. Always ask your doctor if you can drink alcohol while taking any prescribed medication. Continue to read more about the dangers of mixing alcohol and Bactrim antibiotics.

The effects of this reaction may be experienced as soon as five minutes after you drink alcohol, and the symptoms can become more severe as you drink more alcohol. Bactrim is a commonly prescribed antibiotic used to treat bacterial infections including those in the ear, urinary tract, and respiratory system. You may know it by its generic name, sulfamethoxazole-trimethoprim, or SMZ-TMP. Potentially harmful side effects can occur if you mix alcohol and Bactrim.

How Does Alcohol Interacts With Antibiotics?

In vitro reverse mutation bacterial tests according to the standard protocol have not been performed with sulfamethoxazole and trimethoprim in combination. An in vitro chromosomal aberration test in human lymphocytes with sulfamethoxazole/trimethoprim was negative. In in vitro and in vivo tests in animal species, sulfamethoxazole/trimethoprim did not damage chromosomes.

An awareness of these limitations can be used to inform future, higher-quality studies. Toxicity/ADR. Ethionamide package labeling recommends against excessive alcohol consumption . Ethionamide, often used in combination with pyrazinamide, is known to cause hepatotoxicity . An observational study of 55 alcoholics with TB found that mild liver impairment in alcoholics is not a contraindication for treatment with ethionamide . Of the 55 patients in that study, 30 received ethionamide and three patients developed parenchymal liver damage.

Although Transcend Recovery Community doesn’t have a treatment facility, it partners with its sister programs which focus on key areas of long-term rehabilitation. The CDC states that 1 in 3 antibiotic prescriptions are unnecessary. As a consequence, antibiotic misuse has become more common leading to more severe hospitalizations and deaths in the country. Same with Bactrim and alcohol, Transcend Recovery Community surveys how this combination can endanger lives while discussing how it may impact a person’s overall health and wellbeing. Medical detoxis often considered the first stage of treatment.

bactrim and alcohol

RxList does not provide medical advice, diagnosis or treatment. Instruct patients to maintain an adequate fluid intake in order to prevent crystalluria and stone formation. Advise nursing women to avoid breastfeeding during treatment with BACTRIM. BACTRIM has been shown to be active against most isolates of the following microorganisms, both in in vitro and in clinical infections . Approximately 44% of trimethoprim and 70% of sulfamethoxazole are bound to plasma proteins.


First-generation sulfonylureas have been reported to cause facial flushing when administered with alcohol, via inhibition of acetaldehyde metabolism (76,–79). As these compounds are chemically related, the occurrence of a disulfiram-like reaction with TMP-SMX seems mechanistically plausible. Trimethoprim-sulfamethoxazole (TMP-SMX) is used for urinary tract infections and pneumocystis infections . Historical studies have suggested that alcohol use with nitrofurantoin resulted in a disulfiram-like reaction (40,–42). Likewise, a study found that alcohol did not cause a disulfiram-like reaction with nitrofurantoin in volunteers .

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  • Acute intake of alcoholic beverages does not interfere with the PK of doxycycline to an extent that would affect its therapeutic levels.
  • Even though there are warnings not to consume alcohol on most antibiotic packaging, it is a common misconception that drinking while on these medications is a relatively safe practice.
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Mixing antibiotics like Bactrim / Sulfamethoxazole and alcohol can cause unsafe heart rate elevation and decreased blood pressure. Children 2 months of age and older—Dose is based on body weight and must be determined by mash certified sober homes your doctor. Occasionally, alcohol consumption may interfere with the efficacy of medications, such as antibiotics. Drinking alcohol can even cause interactions that may convert a particular drug into a toxic substance.

Sulfamethoxazole And Trimethoprim (Oral Route)

However, the dose is usually not more than 1600 mg of sulfamethoxazole and 320 mg of trimethoprim per day. If you want to avoid alcohol and Bactrim being in your system at the same time, wait at least 3 days. Waiting for this period of time will greatly reduce the risk of any type of reaction. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.

Two of these cases may have been related to the concurrent use of pyrazinamide . The effects of alcohol abuse on the body extend beyond the negative eco sober house ma health consequences. Alcohol abuse can also affect family and social relationships, work life, ability to achieve goals, finances, and more.

Bactrim and Alcohol Reaction

Griseofulvin is an oral antifungal approved for the treatment of various ringworm infections due to Microsporum, Epidermophyton, and Trichophyton . Nitroimidazoles are used for parasitic or anaerobic infections . The most common example is metronidazole; however, tinidazole and secnidazole are also members of this class.

Doctors rarely advise that a patient drink alcohol with any type of medication. This is because using alcohol with a prescription can sometimes lead to unexpected results including ineffectiveness and serious side effects. While some antibiotics may be taken with moderate alcohol consumption, Bactrim is not one of them.

Weighing 16 kg—2 teaspoonfuls or 1 tablet 4 times a day for 14 to 21 days. Weighing 24 kg—3 teaspoonfuls or 1 ½ tablets 4 times a day for 14 to 21 days. Weighing 32 kg—4 teaspoonfuls or 2 tablets 4 times a day for 14 to 21 days. Weighing 40 kg—5 teaspoonfuls or 2 ½ tablets 4 times a day for 14 to 21 days. Weighing 48 kg—6 teaspoonfuls or 3 tablets (or 1 ½ DS tablets) 4 times a day for 14 to 21 days.